Synthesis of lycopene (INSNo. 160 d) as a coloring agent (GB2760-2011 "standards of using food additives"), is used to drink (except water packaged), the maximum amount of 15 mg/kg; Candy, the biggest lycopene for skin usage 60 mg/kg; Solid soup, the maximum usage of 390 mg/kg; Semi solid compound seasonings, 40 mg/kg (above all pure lycopene). Lycopene is also used in oxidation, enhance immunity function such as health food. Food additives joint expert committee (JointFAO/WHOExpertCommitteeonFoodAdditives, JECFA) in 2006 that lycopene can be used as a pigment and nutrient supplements.
The European Union in 2008 will contain the vitamin and mineral food supplements into 6 categories (amino acids, enzymes, source of essential fatty acids, probiotics, plant material, other classes), lycopene is listed as "other". And successively in 2009 approved the synthesis Lycopene, natural lycopene, from three spore brady's mildew (Blakesleatrispora) extraction of lycopene as a new food ingredients into the market, also approved from oil extraction of lycopene in tomato products mulberry leaf extract weight loss as a special treatment with the new food Points.
Australia/New Zealand think extract lycopene from tomato for non-traditional food, nor a new resource food, but make sure no safety issues and approved as a food additive, number is 160 d, can be used as colorants and dietary supplements.
International codex alimentarius commission (CodexAlimentariusCommission, CAC) approval for 3 kinds of source of lycopene, which tomatoes extraction, three spore blah mildew extraction and artificial synthesis of lycopene (INSNo. 160 d) for food colorant, and recognition Don't need to make sure the ADI value.
In 2006, the integrity of nutritional health products association (CouncilforResponsibleNutrition, USA) has carried on the risk assessment to lycopene, proposed "the safety of the observed phycocyanin spirulina dose (ObservedSafeLevel, OSL)" is 75 mg/d. The ev aluation of Assessment is based on the published 2006 years ago and more than 30 peer-reviewed human intervention study. In these experiments, the maximum dose of 150 mg/d (intake for 7 days); Followed by 75 mg/d (15 healthy adults for 28 days).
The longest Time was 140 days (13.3 mg/d) healthy adults, were not observed adverse effects, therefore, cannot be deduced can tolerate the highest intake (TolerableUpperIntakeLevel, UL). According to the OSL calculated by animal experimental data for 270 mg/d.
Lycopene soft capsule is mainly with antioxidant, enhance immunity, anti-aging effect. Clinical studies have found that lycopene can enhance immunity, fitness, and helps to reduce uv damage to skin, improve skin aging and age spots.
In addition, you can through the antioxidant effect inhibiting oxidative free radical, reduces the risk of tumor, inhibit the growth of tumor, including breast, lung, stomach and endothelium cancer cell growth. Lycopene can inhibit the formation of atherosclerosis, improve Hypertension, hyperlipidemia, coronary heart disease and other disease of heart head blood-vessel. This product rosmarinic acid supplement are not found in current clinical adverse reactions, patients can be at ease use. There is no clear basis confirmed that lycopene is the drug treatment of hyperplasia of prostate, but lycopene Is of great help to prevent before adenocarcinoma, help in the treatment of prostatitis.